Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process
نویسندگان
چکیده
منابع مشابه
Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection
Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providing a conduit for the viral genome to enter the cytoplasm and initiate replication. In a concurrent study, we identified clomiphene as a potent inhib...
متن کاملInterfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By Sambucus Nigra
Sambucus nigra (elder) are broadly used species to treat microbial infections. Thepotential antiviral activity and mechanism action of elder fruit (EF) in human epithelium cell(A549) cultures infected with H9N2 influenza virus were determined. The effect of variousconcentrations of EF on influenza virus replication was examined by using virus titration,quantitative real time RT-PCR, fusion and ...
متن کاملMolecular docking study of anti-viral FDA-approved drugs as novel entry and replication Ebola viral inhibitors
Background & Objective: Because of the reported high ability of virulence and the lack of appropriate drug of Ebola virus during the last decades, many investigations have been accomplished regarding discovery and the introduction of anti-Ebola drugs. The aim of this research was the bioinformatical study of entry and replication of Ebola viral inhibition by drug repurposing. Materials & Method...
متن کاملLegume Lectins Inhibit Human Parainfluenza Virus Type 2 Infection by Interfering with the Entr
Three lectins with different sugar binding specificities were investigated for anti-viral activity against human parainfluenza virus type 2 (hPIV-2). The lectins, concanavalin A (Con A), lens culinaris agglutinin (LCA) and peanut agglutinin (PNA), inhibited cell fusion and hemadsorption induced by hPIV-2. Virus nucleoprotein (NP) gene synthesis was largely inhibited, but fusion (F) and hemagglu...
متن کاملInterfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By Sambucus Nigra
Sambucus nigra (elder) are broadly used species to treat microbial infections. Thepotential antiviral activity and mechanism action of elder fruit (EF) in human epithelium cell(A549) cultures infected with H9N2 influenza virus were determined. The effect of variousconcentrations of EF on influenza virus replication was examined by using virus titration,quantitative real time RT-PCR, fusion and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pathogens and Disease
سال: 2015
ISSN: 2049-632X
DOI: 10.1093/femspd/ftv032